An allele separating skeletal patterning and spermatogonial renewal functions of PLZF
نویسندگان
چکیده
منابع مشابه
Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1
Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion, although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptors required to transduce niche-derived signals. We find that SPCs lacking Plzf, a transcription f...
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ROS are required for mouse spermatogonial stem cell self-renewal.
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2010
ISSN: 1471-213X
DOI: 10.1186/1471-213x-10-33